WebJan 25, 2024 · By comparative transcriptome analysis of mouse taste receptor cells, we identified Otopetrin1 (OTOP1), a protein required for development of gravity-sensing otoconia in the vestibular system, as forming a proton-selective ion channel. We found that murine OTOP1 is enriched in acid-detecting taste receptor cells and is required for their … WebMay 25, 2004 · Otopetrin1 gene located on mouse chromosome 5. The consequence of such a mutation leads to a disruption of the transcription of the gene. Conclusions. The identification of the ied knock-down allele strengthens the role of the Otopetrin1 in the sensing of balance.
Otopetrin 1 activation by purinergic nucleotides regulates ...
WebFeb 6, 2008 · Otopetrin1 (Otop1) is the first described member of the otopetrin family, a novel gene family that encodes multi-transmembrane domain proteins. The family was named for the conserved role of Otop1 in the formation of otoconia and otoliths – "oto" (ear) and "petros" (stone). Otoconia are complex calcium carbonate biominerals in the utricle … Webof a spontaneous recessive mutation in the Otopetrin1 gene on chromosome 5 that is thought to alter regulation of the pH level of the inner ear so that otoconia, calcium carbonate crystals, cannot form (Hurle et al. 2003). The otoconia provide the inertial mass needed to stimulate the otolith sensory hair cells during head acceleration or tilt. dawn norvell walmart
Otopetrin 1 activation by purinergic nucleotides regulates ...
WebJul 17, 2007 · Otopetrin1 (Otop1) is a multitransmembrane domain protein required for the formation of otoconia in the vertebrate inner ear. Otoconia are complex calcium … WebJan 26, 2024 · Otopetrin1 has recently been identified as mammalian sour taste receptor which is essential for acid sensation. However, whether other Otopetrin proteins are … WebChronic low-grade inflammation is emerging as a pathogenic link between obesity and metabolic disease. Persistent immune activation in white adipose tissue (WAT) impairs … dawn notts