Epcam function
WebDec 1, 2024 · At the core of EpCAM (and EpCAM2/Trop2) function stands the ability to repress contractility of the actomyosin cell cortex. This activity appears to involve direct inhibition by EpCAM of members of the novel PKC family and of a specific downstream PKD-Erk cascade. WebMar 12, 2012 · To gain insight into EpCAM function in a physiologic context in vivo, we generated conditional knockout mice with EpCAM-deficient LC and characterized them. Epidermis from these mice contained increased numbers of LC with normal levels of MHC and costimulatory molecules and T-cell–stimulatory activity in vitro. Migration of EpCAM …
Epcam function
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WebApr 13, 2024 · EpCAM deficiency causes congenital tufting enteropathy (CTE) which is considered as one kinds of very early onset inflammatory bowel disease (IBD). However, functions of EpCAM on regulating the immunity of intestines are still unclear. To study the mechanism of EpCAM on maintaining the intestinal immune homeostasis, the intestines … WebFunctions of EpCAM in physiological processes and diseases (Review) EpCAM (epithelial cell adhesion molecule) is a type I transmembrane glycoprotein, which was …
WebDec 30, 2024 · Epithelial cell adhesion molecule (EpCAM) is a cell surface protein that was discovered as a tumour marker of epithelial origins nearly four decades ago. EpCAM is expressed at basal levels in the basolateral membrane of normal epithelial cells. However, EpCAM expression is upregulated in solid epithelial cancers and stem cells. EpCAM can … WebHowever, the function and molecular mechanism of BMSC-exos in sepsis-induced AECII apoptosis remain to be elucidated. In the present study, a more significant ... FSC hi SSC hi, singlet, Lin − EpCAM + cells were the primary AECII population. And the purity was assessed by the expression of pro-SP-C, a specific marker for AECII cells. Double ...
WebFeb 21, 2024 · Isolated single cells were sorted on the basis of CD45, CD3, or epithelial cell adhesion molecule (EpCAM) expression to sample thymocytes and enrich for non … WebEp-CAM functions as a homotypic calcium-independent cell adhesion molecule, and has a direct impact on cell cycle, proliferation and metabolism of epithelial cells and fibroblasts …
WebDec 1, 2024 · At the core of EpCAM (and EpCAM2/Trop2) function stands the ability to repress contractility of the actomyosin cell cortex. This activity appears to involve direct …
WebApr 12, 2024 · We compared the effector functions and cytotoxicity of these CAR-T cell variants against a group of tumor cell lines with a wide range of EpCAM expression as well as human primary epithelial cells ... chaloem ratchamongkhonWebFeb 19, 2024 · The epithelial cell adhesion molecule (EpCAM) is one of the most frequently and intensely expressed of tumor-associated antigens, but the role that EpCAM plays in the proliferation, adhesion and migration properties of cancer cells remains unclear. In the present study, we screened several tumor cell lines and found that colorectal … chaloeil dofusWebFeb 1, 2012 · EpCAM is a type I, transmembrane, 39–42 kDa glycoprotein that functions as a homophilic, epithelial-specific intercellular cell–adhesion molecule. [10], [11], [12] The 314 amino acid-long EpCAM protein comprises a large extracellular domain with an epidermal growth factor (EGF)-like domain and a putative thyroglobulin (TY) domain, a … chalofenstrasseWebMar 21, 2024 · EPCAM (Epithelial Cell Adhesion Molecule) is a Protein Coding gene. Diseases associated with EPCAM include Diarrhea 5, With Tufting Enteropathy, … chaloem phrakiat agricultural museumhappy nails grayton beachWebEpCAM (epithelial cell adhesion molecule) was discovered four decades ago as a tumor antigen on colorectal carcinomas. Owing to its frequent and high expression on … happy nails grayton beach flThe exact function of EpCAM is currently being elucidated, but EpCAM appears to play many different roles. EpCAM was first found to play a role in homotypic cell adhesion. This means that EpCAM on the surface of one cell binds to the EpCAM on a neighboring cell thereby holding the cells together. The adhesions mediated by EpCAM are relatively weak, as compared to some other adhesion … happy nails kelowna