Dek c terminal domain containing protein
WebJan 2, 2009 · For DNA binding experiments, amino acids 68–194 from human DEK were ligated into the bacterial expression vector pET30a (Novagen) as a fusion protein with … WebA leucine-rich repeat (LRR) is a protein structural motif that forms an α/β horseshoe fold. [1] [2] It is composed of repeating 20–30 amino acid stretches that are unusually rich in the hydrophobic amino acid leucine. …
Dek c terminal domain containing protein
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WebStructural assembly of two-domain proteins by rigid-body docking. Cheng TM, Blundell TL, Fernandez-Recio J. BMC Bioinformatics 9 441 (2008) Solution NMR structure of the C-terminal domain of the human protein DEK. Devany M, Kotharu NP, Matsuo H. Protein Sci 13 2252-2259 (2004) Molecular Topology of RNA Polymerase I Upstream Activation … WebApr 1, 2005 · The 375-residue human protein DEK is a proto-oncogene protein that is associated with chromatin [1]. DEK was first discovered in patients with a subtype of acute myelogenous leukemia (AML) as a fusion product in which its C-terminal 26 amino acids are replaced by the N-terminal two-thirds of the nucleoporin CAN [2].
WebThe C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH). When the protein is translated from messenger RNA, it is created from N-terminus to C-terminus. The convention for … WebDEK was originally described as a proto-oncogene protein and is now known to be a major component of metazoan chromatin. DEK is able to modify the structure of DNA by introducing supercoils. In order to find interaction partners and functional domains of DEK, we performed yeast two-hybrid screens and mutational analyses. Two-hybrid screening …
WebFeb 1, 2016 · The DEK_C domain is related to the C-terminal of animal DEK protein, which is responsible for self-multimerization and DNA binding ( Kappes et al., 2004 ). Nevertheless, the role of the DEK_C domain in …
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WebSep 1, 2004 · The 375 amino acid human protein DEK contains two functional structured domains, namely the N-terminal domain (amino acids 68-226) and the C-terminal domain (amino acids 309-375) (18, 19). In the ... make sharepoint page a templateWebMar 20, 2024 · DEK is a highly conserved chromatin-bound protein whose upregulation across cancer types correlates with genotoxic therapy resistance. Loss of DEK induces genome instability and sensitizes... make sharepoint site read onlyWebDec 8, 2004 · The protein DEK is an abundant and ubiquitous chromatin protein in multicellular organisms (not in yeast). ... SSH1 also contains a DEK-C domain in the N-terminal region. The N-terminal fragment of SSH1 bound to and co-localized with F-actin, but mutation at Arg-96 or a Leu-His-Lys (LHK) motif in the PH-like domain reduced this … make sharepoint page publicWebDEK is a chromatin associated protein that is linked with cancers and autoimmune disease. This domain is found at the C terminal of DEK and is of clinical importance since it can reverse the characteristic abnormal DNA-mutagen sensitivity in fibroblasts from ataxia-telangiectasia (A-T) patients [ 3 ]. The structure of this domain shows it to be ... make sharepoint show up in file explorerWebSolution NMR structure of the N-terminal domain of the human DEK protein Protein Sci. 2008 Feb;17(2):205-15. doi: 10.1110/ps.073244108. ... We found that not only the C … make sharper crossword clueWebAug 1, 2004 · We also found two DNA binding domains of DEK, one on a fragment including amino acids 87 to 187 and containing the SAF-box DNA binding motif, which is located between amino acids 149 and 187. make sharepoint site public to all usersWebEnter the email address you signed up with and we'll email you a reset link. make sharepoint public